Investigating the association between retinal layer measurements and cognitive function in adults


  • Macular ganglion cell layer (mGCL) volume had a stronger association with adult cognitive function than peripapillary retinal nerve fiber layer (pRNFL) thickness.

  • The strength and direction of these associations were influenced by age, vascular health factors and smoking status.

Why this matters

    The moderating effects of vascular health factors on the validity of using retinal measurements as a biomarker for cognitive function had not previously been explored.