Investigating the distribution of corpus callosum atrophy in multiple sclerosis


  • Corpus callosum (CC) damage develops following a postero–anterior gradient in patients with progressing multiple sclerosis (MS), which is associated with clinical disability.

Why this matters

  • Advanced neuroimaging techniques have demonstrated that damage to the CC occurs with disease progression in MS; however, the topography, timeline and relationship of callosal atrophy to clinical disability remain unclear.

  • This study provides some clarification on the mechanisms of interhemispheric disconnection behind callosal atrophy, and the associated impact on clinical disability in MS.