Investigation of cerebrospinal fluid biomarkers along the Alzheimer’s disease continuum


  • While cerebrospinal fluid (CSF) tau increases with age as a result of normal aging, this biomarker decreases with age for those with Alzheimer’s disease (AD).

Why this matters

  • CSF total tau (t-tau) and phosphorylated tau (p-tau) may be useful biomarkers for AD in clinical trials.