Patients with amyotrophic lateral sclerosis (ALS) experience behavioral decline regardless of their cognitive-behavioral profile, with different levels of insight loss between subgroups, and higher pre-morbid verbal intelligence is associated with poorer insight.
Why this matters
Cognitive-behavioral impairment exists in approximately half of ALS patients with disease spectrum of fronto-temporal dementia (ALS-FTSD) and the most frequent symptoms of such impairment are perseveration, apathy, and disinhibition, which may also be accompanied by loss of insight into disease-related impairment. However, variations in insight between different ALS Strong criteria subgroups, and between different premorbid intelligence levels, have not been studied.
This study provides evidence of behavioral decline differences between ALS subgroups, which may aid in future therapeutic approaches.