Investigation of loss of “insight” into behavioral changes according to amyotrophic lateral sclerosis cognitive profiles


  • Patients with amyotrophic lateral sclerosis (ALS) experience behavioral decline regardless of their cognitive-behavioral profile, with different levels of insight loss between subgroups, and higher pre-morbid verbal intelligence is associated with poorer insight.

Why this matters

  • Cognitive-behavioral impairment exists in approximately half of ALS patients with disease spectrum of fronto-temporal dementia (ALS-FTSD) and the most frequent symptoms of such impairment are perseveration, apathy, and disinhibition, which may also be accompanied by loss of insight into disease-related impairment. However, variations in insight between different ALS Strong criteria subgroups, and between different premorbid intelligence levels, have not been studied.

  • This study provides evidence of behavioral decline differences between ALS subgroups, which may aid in future therapeutic approaches.