Investigation of the “nodal stress” hypothesis in relapsing remitting multiple sclerosis


  • In cognitively impaired (CI) multiple sclerosis (MS) patients, abnormal functional connectivity (FC) occurs simultaneously with altered structural connectivity and cerebral blood flow (CBF) in resting state network (RSN) regions.

Why this matters

  • The “nodal stress” hypothesis proposes that high activity in areas with high FC makes them susceptible to pathological wear and tear, accelerating neurodegeneration and leading to network dysfunction.

  • Additionally, nodal damage may impact CBF.

  • Results from this study, evaluating diffusion magnetic resonance imaging (MRI) and CBF data with resting state functional MRI (rs-fMRI) images, supports the “nodal stress” hypothesis and can inform future research for MS.