Iron deposits in periaqueductal gray matter relate with clinical and molecular markers of migraine

Takeaway

  • Iron deposits in periaqueductal gray matter (PAG) were higher in people with chronic migraine (CM) than in those with episodic migraine (EM) and controls, were associated with markers of endothelial dysfunction and blood-brain barrier disruption, and correlated with presence of CM.

Why this matters

  • PAG iron deposition is a potential marker of CM although whether these deposits are irreversible or reversible should be investigated.