Is aortic stiffness associated with neuropathological biomarkers?


  • Age-related arterial stiffening was associated with biomarkers of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration in participants >73 years.

Why this matters

  • Arterial stiffening has been associated with cognitive impairment and structural brain changes, due to increases in blood pulsatility that damage cerebral microcirculation, leading to reductions in blood flow.

  • The pathological pathways initiated or exacerbated by these microcirculatory alterations are unknown.