Is G protein-coupled receptor 151 involved in the pathogenesis of neuropathic pain?


  • G protein-coupled receptor 151 (GPR151) knockout in nociceptive dorsal root ganglion (DRG) neurons inhibited neuropathic pain-like behavior in a chronic constriction injury (CCI)-induced mouse model.

Why this matters

  • Neuropathic pain is a debilitating condition that affects up to 7–10% of the population.

  • The mechanisms underlying neuropathic pain remain unclear, and the discovery of novel, efficacious treatment targets is of critical importance.