Is retinal neurodegeneration associated with late-life depression?


  • Lower retinal nerve fiber layer (RNFL) thickness was associated with a significantly higher incidence of depressive symptoms and more depressive symptoms over time.

Why this matters

  • Late-life depression is associated with a high comorbidity of psychiatric and physical diseases, including Alzheimer’s disease.

  • Monitoring retinal neurodegeneration in older adults may improve identification of individuals at risk of late-life depression.