Is the adaptive immune system dysregulated in early Parkinson’s disease?

Takeaway

  • T and B cell subsets and their respective cytokine expression profiles significantly differed between healthy controls (HCs) and patients with early Parkinson’s disease (PD).

Why this matters

  • Evidence indicates a role for the adaptive immune system in PD pathogenesis, but the contribution of T cells and B cells has not been well studied.

  • The dysregulation of various T cell and B cell subsets detected in these patients with PD may encourage the development of future therapies targeting the adaptive immune system.