Is the Expanded Disability Status Scale the most useful measure of disability in multiple sclerosis?


  • Comparing the Expanded Disability Status Scale (EDSS), timed 25-foot walk (T25FW) and 9-hole peg test (NHPT) in a randomized controlled trial (RCT) of relapsing remitting multiple sclerosis (RR-MS) showed that T25FW may be more useful as a measure of disability than the EDSS.

Why this matters

  • RCTs typically use the EDSS as the primary outcome measure of disability in MS trials.

  • These results suggest that the T25FW was less prone to noise and measurement errors than the EDSS, and RCTs may benefit from using the T25FW as the primary disability outcome measure.