Is there a link between vigorous physical activity and early-onset amyotrophic lateral sclerosis?


  • Patients with a history of vigorous physical activity (VPA) in adolescence and early adulthood were significantly more likely to be diagnosed with ALS before the age of 60.

Why this matters

  • Amyotrophic lateral sclerosis (ALS) is a complex multifactorial neurodegenerative disease that typically results in death within 2–5 years from diagnosis. Risk factors and causes of the disease are still largely unknown.

  • Improving understanding of VPA as an ALS risk factor may help clinicians make more rapid diagnoses and result in earlier therapeutic interventions.