L-α Glycerylphosphorylcholine use is linked to increased stroke risk after 10 years


  • L-α glycerylphosphorylcholine use is associated with a higher 10-year incident stroke risk in a dose-response manner independent of cerebrovascular risk factors.

Why this matters

  • The choline analogue, L-α glycerylphosphorylcholine, is used globally as a dietary supplement to improve cognitive function in older adults; however, there are concerns that high levels of choline increase the risk of stroke.

  • This cohort study in more than 12 million older adults without stroke risk factors reveals that L-α glycerylphosphorylcholine use is linked to a 10-year incident stroke risk in a dose-responsive manner; the decision to use L-α glycerylphosphorylcholine must therefore be carefully balanced with the potential stroke risk.