Amiloride, fluoxetine and riluzole show a lack efficacy in people with secondary progressive multiple sclerosis (MS) treated in the MS-SMART trial.
Why this matters
Few treatments are currently available that can slow, stop or reverse progressive MS. It remains unclear if directly targeting axonal pathobiologies is an effective therapeutic strategy.
Multiarm trials such as MS-SMART offer a way to accelerate treatment discovery by assessing multiple disease-modifying treatments at the same time.
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