Language plasticity and functional connectivity in epilepsy

Takeaway

  • Functional connectivity, as assessed using resting-state functional magnetic resonance imaging (fMRI), may be reflective of network plasticity and can expand on traditional task-based fMRI for the assessment of language networks in children with epilepsy.

Why this matters ?

  • Prior to epilepsy surgery, localization of the language network must occur, which may be performed using task-based fMRI language mapping. However, there are limitations to this approach.

  • Resting-state functional connectivity could provide an alternative, with distinct advantages in identifying lateralized language networks and predicting post-surgical language decline. However, further exploration of this approach is needed.