Large-scale genomic study on physical exercise as a risk factor for amyotrophic lateral sclerosis

Takeaway

  • A positive causal relationship was identified between strenuous physical exercise and amyotrophic lateral sclerosis (ALS).

Why this matters

  • Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease thought to be caused by complex interplay between genetic and environmental factors.

  • Exercise has been suggested as risk for ALS, but data to date have been inconclusive. Use of Mendelian randomization (MR) counters bias and confounding variables that have limited previous analyses.