Lesion patterns and structural dysconnectivity associated with post-stroke aprosodia and amusia


  • In post-stroke patients, disconnections of the right inferior fronto-occipital fasciculus (IFOF) and lesions along the right ventral stream are involved in linguistic and affective prosodic deficits, and similar lesion configurations are seen in both pitch and rhythm amusia.

Why this matters

  • While aprosodia (i.e., inability to recognize speech melody and rhythm) and amusia (i.e., deficit in processing rhythmic-melodic acoustic patterns in music) have been associated with stroke, there are few comparative studies evaluating shared neuroanatomical features.

  • Results of this study suggest that stroke patients with right ventral stream damage should be evaluated for deficits in prosody and musical perception, and personalized treatment plans should be developed to impact patient well-being.