Lesions with paramagnetic rims are associated with earlier onset of disability in multiple sclerosis

Takeaway

  • In people with multiple sclerosis (MS), presence of lesions with rims on brain imaging scans was associated with earlier onset of motor and physical disability and progressions of lesions over time.

Why this matters

    The outcome measures used here (including imaging paramagnetic rim lesion development) could be useful in clinical trials addressing chronic inflammation around MS lesions.