Leucine zipper 4 autoantibody: a potential biomarker in germ-cell tumors

Takeaway

  • The leucine zipper 4 (LUZP4) antigen is a potential serological biomarker of germ-cell tumors and associated paraneoplastic neurological syndrome (PNS).

Why this matters

    The use of LUZP4 as a serological biomarker in PNS may be a useful tool to assist in detecting underlying cancer pathology in those with occult tumors with paraneoplastic neurological presentations.