Level of cognitive reserve has opposing effects on progression of Alzheimer’s disease


  • Greater ‘cognitive reserve’ (CR) – the mind’s resilience to brain damage – is related to lower risk of diagnostic conversion in early Alzheimer’s disease (AD) but faster cognitive decline in progressed disease.

Why this matters

    CR has been associated with slower cognitive decline in early AD and clinical progression in advanced AD, but few studies have assessed the effects of CR across the AD spectrum. Doing so may provide a key to more accurate prognoses for patients with AD.