Leveraging heterogeneous data to study developmental cognitive neuroscience

Speaking at the CNS 2021 annual meeting, Dr Alexander Cohen, from Boston Children’s Hospital, Massachusetts, USA, presented approaches to address heterogeneity in research data and patients, while studying the development of behavior as well as the development of brain structure and function.

Traditional cognitive and developmental neuroscience has been based on group level comparisons. However, in the recent past, the patient population has become much less dichotomous, and grouping results into obvious clusters or phenotypes has become a challenge, especially when dealing with measures where the effect sizes are much smaller.