Lewy pathology in Parkinson’s disease

Takeaway

  • Ultrastructural analysis of Lewy body (LB) and Lewy neurite (LN) inclusions in Parkinson’s disease (PD) revealed a crowded environment of membranes, including vesicular structures and dysmorphic organelles.

Why this matters

  • The identification of lipids as a major component of LB/LN has implications for the development of cellular and in vivo models of PD, development of biomarkers such as positron emission tomography tracers for Lewy pathology, and development of new drug targets.