Link between blood-brain barrier impairment and hypoperfusion in cerebral small vessel disease


  • The blood brain barrier (BBB) is impaired and cerebral blood flow (CBF) is reduced near to white-matter hyperintensities (WMH). High BBB impairment also correlates with lower CBF in both WMH and normal-appearing white matter (NAWM).

Why this matters ?

  • There is a correlation between BBB and CBF in Alzheimer’s disease, but such a link has not been investigated in cerebral small vessel disease (cSVD). If there was a link, then these features could inform treatment strategy.