Locoregional administration of cytotoxins for the treatment of spontaneous intracranial gliomas

Takeaway

  • Convection enhanced delivery (CED) of cytotoxins targeting interleukin 13 receptor alpha 2 (IL13RA2) and ephrin type-A receptor 2 (EPHA2) receptors was well-tolerated and resulted in clinically relevant responses in dogs with spontaneous intracranial glioma.

Why this matters

    Findings from this canine model provide insights into the locoregional administration of multi-receptor targeted therapy in spontaneous intracranial glioma, which can be further investigated to identify novel delivery and treatment strategies for glioma in humans.