Long-term cognitive decline linked to neurofilament light chain in frontotemporal lobar degeneration


  • Cerebrospinal fluid neurofilament light chain can differentiate between people with known frontotemporal lobar degeneration pathology and healthy controls.

Why this matters

    There is a pressing need for accurate diagnosis and prognosis of frontotemporal lobar degeneration, especially with emerging disease-modifying treatments. There are limited cerebrospinal fluid biomarkers that have been validated longitudinally in people with known pathology; these novel findings suggest that neurofilament light chain could fill this gap.