Individuals with a single history of unilateral optic neuritis (HON) had long-term structural damage within the retina and the optic radiation (OR) which suggests retrograde and anterograde neuroaxonal degeneration.
Why this matters
Long-term impacts of acute clinical episode of optic neuritis (ON) in individuals with multiple sclerosis (MS) are not well understood. Combining magnetic resonance imaging (MRI) and optical coherence tomography (OCT) scans can help probe the entire visual pathway. Many studies have used OCT and MRI in studies of MS, but many have not considered the timespan after a clinical episode of MS. The results of this study document the long-term structural changes between individuals with MS with and without clinical ON.