Disconnection of a hypothalamic hamartoma (HH) from the hypothalamus using stereotactic radiofrequency thermocoagulation (SRT) provided long-term freedom from gelastic seizures (GS); non-(n)GS freedom outcomes are likely dependent on non-surgical factors.
Why this matters
An HH is a tumor-like lesion associated with a unique epilepsy phenotype involving GS. Patients may also experience nGS and behavioral and intellectual abnormalities.
Seizures in HH are typically drug-resistant and require treatment with ablation surgery such as SRT; however, there is limited understanding of the long-term clinical impact of various ablation surgeries that would allow for tailored treatment recommendations.