Long-term follow-up of multiple system atrophy parkinsonian and cerebellar subtypes

Takeaway

  • In a study of individuals with multiple system atrophy (MSA), apathy increased over long-term follow-up overall, while those with the parkinsonian subtype (MSA-P) had wide ranging worsening of cognitive function and those with the cerebellar subtype (MSA-C) showed a decline in processing speed.

Why this matters

  • Cognitive and neuropsychological manifestations of MSA evolve over the course of the disease, suggesting the importance of continued evaluation of cognitive and psychiatric features in clinical practice.

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