Long-term neurological risks of tau isoform distribution in chronic traumatic encephalopathy

Takeaway

  • Tau isoform composition in chronic traumatic encephalopathy  (CTE) exhibits similarities with ageing and Alzheimer’s disease and may be an indicator of the long-term neurological risks of traumatic brain injury (TBI).

Why this matters

  • There is increasing evidence to support the association between TBI and subsequent neurodegenerative diseases, in particular, CTE.

  • Currently, CTE is diagnosed by the presence of phosphorylated-tau aggregates in neurons, astrocytes, and cell processes around small vessels in an irregular pattern at the depths of the cortical sulci.

  • A greater understanding of the morphological and phenotypic characteristics of CTE may help to elucidate similarities and differences with other tau-mediated neurodegenerative disorders and understand the potential neurological risks associated with TBI.