Tau isoform composition in chronic traumatic encephalopathy (CTE) exhibits similarities with ageing and Alzheimer’s disease and may be an indicator of the long-term neurological risks of traumatic brain injury (TBI).
Why this matters
There is increasing evidence to support the association between TBI and subsequent neurodegenerative diseases, in particular, CTE.
Currently, CTE is diagnosed by the presence of phosphorylated-tau aggregates in neurons, astrocytes, and cell processes around small vessels in an irregular pattern at the depths of the cortical sulci.
A greater understanding of the morphological and phenotypic characteristics of CTE may help to elucidate similarities and differences with other tau-mediated neurodegenerative disorders and understand the potential neurological risks associated with TBI.