Long-term omega-3 use for the prevention of Alzheimer’s disease in at-risk individuals


  • Regular omega-3 supplementation may reduce the risk of Alzheimer’s disease (AD) in carriers of apolipoprotein E (APOE) ε4, suggesting that genetic risk factors of AD could be improved, and their adverse effects diminished by long-term omega-3 supplementation.

Why this matters

  • Carriers of the APOE ε4 gene have a 3–12-fold increased risk of late-onset AD, but it is unclear whether this genetic risk can be modified by environmental factors.

  • Omega-3 has been proposed to interact with APOE ε4 and influence AD risk.

  • As dietary interventions are easily adoptable for primary prevention, understanding the interaction between omega-3 and APOE ε4 may aid AD prevention in at-risk populations.