Long-term response of patients undergoing Gamma Knife radiosurgery for cavernous sinus meningioma


  • Gamma Knife radiosurgery (GKRS) with a margin dose of 11–13 Grays (Gy) provides long-term tumor control and is associated with low cranial nerve-related morbidity (CNRM) in people with cavernous sinus meningioma (CSM).

  • Confined tumors could be predictive of tumor control and shorter time to regression (TTR).

Why this matters

  • Stereotactic radiosurgery (RS) for CSM has high 5-year progression-free survival (PFS) rates but high regression rates and incidence of cranial nerve deficits and other morbidities - this study identifies a GKRS margin dose associated with increased tumor control and decreased rates of cranial nerve-related morbidity in those with CSM.