Longitudinal analysis of objectively measured sleep and white matter structure in middle-age

Takeaway

  • Poor sleep, such as short sleep time and low sleep efficiency, is associated with worse white matter microstructure especially in the thalamic radiation, corticospinal tract, uncinate fasciculus, and association tracts in middle-aged and older adults.

Why this matters

  • Better understating of the longitudinal relation between sleep and brain microstructure could explain whether and how poor sleep is a risk factor for brain aging.