Longitudinal atrophy patterns in four MCI subtypes over 3 years

Takeaway

  • The four MCI subtypes demonstrated unique longitudinal cortical atrophy patterns, suggesting that the novel subtypes accurately reflect underlying atrophy and may therefore have important prognostic value in predicting the clinical course of MCI.

Why this matters

    Four MCI subtypes have previously been identified via cluster analysis of neuropsychological assessments: amnestic MCI (memory deficit), dysnomic/amnestic MCI (naming/memory deficits), mixed MCI (impairment in all cognitive domains) and normal group (intact neuropsychological performance despite MCI diagnosis). Identifying possible unique longitudinal atrophy patterns in these subtypes is important for determining whether they have any prognostic value for improving prediction of the clinical progression of MCI.