Longitudinal changes in cholesterol are linked to neurodegeneration in multiple sclerosis

Takeaway

  • Changes in high-density lipoprotein cholesterol (HDL-C) are associated with brain MRI measures of neurodegeneration and lesional injury in multiple sclerosis (MS), suggesting that the cholesterol pathway is associated with MS disease progression.

Why this matters

  • These results support and extend previous findings that changes in cholesterol pathway biomarkers are associated with altered MS disease progression on MRI measures.