Longitudinal tau positron emission tomography changes vary by cognitive ability and age in atypical Alzheimer’s disease

Takeaway

  • Longitudinal decreases in tau positron emission tomography signal in people with atypical Alzheimer’s disease do not occur randomly but are linked to advanced neurodegeneration.

Why this matters

  • Longitudinal positron emission tomography studies of tau accumulation in Alzheimer's disease have reported a reduction in tau signal. This unique study investigated whether these effects are due to technical and statistical error or reflect real pathologic change in Alzheimer’s disease. The findings further our understanding of how the tau positron emission tomography signal behaves across clinical variants and over the disease course and supports the use of in vivo imaging of tauopathy for diagnosis and monitoring of neuropathologic change in Alzheimer’s disease.