There is evidence of progressive visual evoked potential (VEP) latency delay which occurs independent of acute optic neuritis (ON) in individuals with neuromyelitis optica spectrum disorder (NMOSD).
Why this matters
Individuals with NMOSD often experience severe ON and many are positive for aquaporin-4 antibodies (AQP4-Ab). Little is known about whether the pathology of NMOSD is independent from acute attacks.
The results from this study add new insights into the pathophysiology of the NMOSD and suggest that VEP may be a more sensitive functional measure for change than visual acuity.