Longitudinal visual evoked potential study in neuromyelitis optica spectrum disorder


  • There is evidence of progressive visual evoked potential (VEP) latency delay which occurs independent of acute optic neuritis (ON) in individuals with neuromyelitis optica spectrum disorder (NMOSD).

Why this matters

  • Individuals with NMOSD often experience severe ON and many are positive for aquaporin-4 antibodies (AQP4-Ab). Little is known about whether the pathology of NMOSD is independent from acute attacks.

  • The results from this study add new insights into the pathophysiology of the NMOSD and suggest that VEP may be a more sensitive functional measure for change than visual acuity.