Loss of function mutations in the two-pore potassium channel, TRESK, linked to migraine

Takeaway

  • The two-pore potassium channel, TRESK, plays a key role in human nociceptor function and migraine mechanisms.

Why this matters

  • These novel data support a genetic role of specific TRESK mutations in migraine; TRESK could represent a therapeutic target in migraine, with TRESK activators effective in blocking pain.

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