Loss of TREM2 impairs amyloid plaque clearance in Alzheimer’s Disease (AD)

Takeaway 

  • Heterozygous or homozygous loss of TREM2, but not TREM+/R47H is associated with reduced amyloid plaque clearance and microglial characteristics, warranting further mechanistic study.

Why this matters

    Individuals with the TREM+/R47H mutation have a 3-fold increased risk for late-onset AD.