Low buffy coat mitochondrial DNA copy number is a biomarker and mediator of poor stroke outcomes

Takeaway

  • Buffy coat mitochondrial DNA copy number is a novel and robust marker of post-stroke prognosis that may also be a causal determinant of post-stroke outcomes.

Why this matters

  • People who live in low and middle-income countries have a disparate burden of post-stroke complications; being able to use cost-effective predictive biomarkers that mediate post-stroke recovery could improve outcomes. Low buffy coat mitochondrial DNA copy number has been linked to stroke risk and post-stroke mortality, but its prognostic value is unknown.

  • This unique study is the first international multicenter analysis to show that low buffy coat mitochondrial DNA copy number is a potential prognosticator of post-stroke outcomes; the findings could enable better risk stratification and novel targets for stroke treatment.