Lower extremity muscle pathology in myotonic dystrophy type 1 assessed by quantitative MRI

Takeaway

  • Muscle fat fraction, muscle volume, and T2 relaxation time of water may serve as objective biomarkers to assess disease state of skeletal muscles in patients with myotonic dystrophy type 1 (DM1).

Why this matters

  • In DM1, each muscle is affected differently; the use of therapeutic approaches in the management of DM1 therefore requires quantitative biomarkers that can assess disease state and activity in individual muscles.