Magnetic resonance imaging data sheds light on novel potential causes of primary trigeminal neuralgia


  • Significant differences in Meckel cave (MC) morphology were found in patients with primary trigeminal neuralgia (PTN) that may contribute to disease etiology.

Why this matters

  • PTN is a chronic neuropathic pain condition that is typically caused by neurovascular contact (NVC) between the trigeminal nerve and a vessel. However, many patients experience PTN without NVC, suggesting other causes.

  • The MC, also known as the trigeminal cavity, houses the trigeminal nerve and has not previously been implicated in PTN etiology. Further understanding of PTN pathogenesis will improve patient outcomes.