Significant differences in Meckel cave (MC) morphology were found in patients with primary trigeminal neuralgia (PTN) that may contribute to disease etiology.
Why this matters
PTN is a chronic neuropathic pain condition that is typically caused by neurovascular contact (NVC) between the trigeminal nerve and a vessel. However, many patients experience PTN without NVC, suggesting other causes.
The MC, also known as the trigeminal cavity, houses the trigeminal nerve and has not previously been implicated in PTN etiology. Further understanding of PTN pathogenesis will improve patient outcomes.