Magnetic resonance imaging in spinal bulbar muscular atrophy and amyotrophic lateral sclerosis

Takeaway

  • Quantitative and semiquantitative skeletal muscle magnetic resonance imaging (MRI) can differentiate between spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS) and can also be used as a biomarker of disease progression.

Why this matters

  • People with ALS and SBMA often have similar symptoms at disease onset, therefore it is important to correctly identify distinguishing features of disease.

  • The lack of a reliable outcome measure for disease progression has previously limited clinical trial development in neuromuscular disease.