Mapping deep brain stimulation connectivity to refine targets for treatment of essential tremor

Takeaway

  • Correlations between brain regions activated during deep brain stimulation (DBS) and clinical outcomes can improve DBS targeting to improve treatment of essential tremor (ET).

Why this matters

  • DBS is an effective therapy for the 25–55% of patients with ET who cannot control tremors with medication, but it is still unclear which brain regions should be stimulated to provide the best results.

  • This study leverages technological advances to better characterize correlations between brain region stimulation and ET outcome to identify DBS targets that may provide more robust symptom improvement in ET.