Mapping dendrite density in the cortex of patients with multiple sclerosis

Takeaway

  • Laminar analysis of cortical tissue in patients with multiple sclerosis (MS) showed cortical damage in patients with MS that was different in patients with relapsing-remitting versus progressive MS.

Why this matters

    In people with MS, it is well established that demyelination and neuroaxonal loss are associated with cortical thinning. Recent research has suggested that loss of dendrite density is also an important pathological feature of MS, which is independent of cortical demyelination, axonal density and cortical thickness. It has been suggested that reduced dendrite density could be detected as a reduction in the T1/T2-weighted ratio. However, it is currently unclear where in the cortical regions this pathology may occur.