Measuring corneal nerve loss in painful diabetic neuropathy


  • Corneal confocal microscopy (CCM) may be useful as a diagnostic tool in painful diabetic neuropathy (PDN), and showed that greater corneal nerve loss was associated with increased pain severity.

Why this matters

  • Approximately one in five adults with diabetes have PDN. It has significant impact on quality of life, and current treatments show limited efficacy.  

  • Accurate diagnosis of PDN will aid in the identification of patients for clinical trials and the subsequent development of more effective treatments.