Measuring laser-evoked potentials in people with chronic pain disorders


  • Laser-evoked potential (LEP) signals and transient power modulations are similar in people with chronic fatigue syndrome (CFS), chronic whiplash-associated disorders (cWAD) and healthy controls.

Why this matters

  • CFS and cWADs may be associated with sensitization of the central nervous system (CNS), however functional analyses of the CNS in these conditions have not been performed.

  • Electrophysiological assessment with LEPs is a useful tool to evaluate functional abnormalities of CNS, with typically enhanced LEPs in syndromes associated with central sensitization.