Measuring sleep disturbances in a mouse model of dravet syndrome

Takeaway

  • Circadian regulation of sleep is affected in Dravet Syndrome (DS) and by measuring sleep disturbances using long-term electrocorticographic (ECoG) recordings, new information may be gained to help treat patients.

Why this matters

  • Children with DS, a form of severe epilepsy, often experience sleep disturbances, cognitive impairment, and sudden infant death.

  • DS is caused by a SCN1A gene mutation which is linked to sleep disturbances through gamma-aminobutyric acid (GABA) reduction.

  • The DS mouse model with a SCN1A deletion demonstrate epilepsy, cognitive impairment, and sleep disturbances.