Measuring spinal cord atrophy in MS

Takeaway

  • Spinal cord cross-sectional area could be a reliable imaging endpoint for clinical trials in people with multiple sclerosis.

Why this matters

    Mobility problems and long-term disability seen in people with multiple sclerosis (MS) are generally linked to spinal cord atrophy. However, location of this atrophy varies between phenotypes, with severe cord cross-sectional area (CSA) reduction seen in some in some individuals with progressive MS. A better understanding of the evolution of disease, and diagnostic biomarkers, would allow physicians to identify patients earlier who might benefit from neuroprotective treatments.