Measuring the retinal nerve fiber layer in hereditary spastic paraplegia


  • Retinal nerve fiber layer (RNFL) thinning, as assessed by spectral domain-optical coherence tomography (SD-OCT), may not be a suitable biomarker for hereditary spastic paraplegia (HSP), rather aging may be more of a specific contributor to RNFL thinning.

Why this matters

    Measuring the RNFL thickness may be a clinical biomarker to monitor neurodegenerative conditions such as HSP. Results of this study suggest a larger more systematic and longitudinal appraisal of RNFL thickness in a larger variety of HSP is needed to help understand its potential use as a biomarker for HSP.