Mechanisms of distal sensory polyneuropathy in HIV

Takeaway

  • In patients with human immunodeficiency virus-associated distal sensory neuropathy (HIV-DSP), pain relief-related processing was significantly altered in those with chronic pain compared to those without.

Why this matters

  • HIV-DSP is a common neurological complication of HIV-1 infection that is not well understood and can lead to the development of chronic neuropathic pain.

  • This study provides evidence for abnormal pain processing in patients with HIV and associated chronic pain.